Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

Research involving estrogen and progesterone receptors (ER and PR) have greatly
contributed to our understanding of cell signaling and transcriptional regulation. In addition …

The estrogen receptors (ERs) are typical members of the superfamily of nuclear receptors
that includes the receptors that mediate the effects of steroid hormones, thyroid hormones …

Breast cancer is the most common cancer and the deadliest among women worldwide.
Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen …

Breast cancer, a most common malignancy in women, was known to be associated with
steroid hormone estrogen. The discovery of estrogen receptor (ER) gave us not only a …

In breast cancer (BC) epithelial cells, the mitogenic action of estradiol is transduced through
binding to two receptors, ERα and ERβ, which act as transcription factors. Anti-estrogens …

Estrogen and estrogen receptors (ERs) are critical regulators of breast epithelial cell
proliferation, differentiation, and apoptosis. Compromised signaling vis-à-vis the estrogen …

Simple Summary Estrogens, belonging to a group of steroid compounds, play an important
role in both physiological and disease processes, mainly by interacting with estrogen …

Estrogens exert their physiological and pathophysiological effects via cellular receptors,
named ERα, ERβ, and G-protein coupled estrogen receptor (GPER). Estrogen-regulated …

Estrogens work along with genetic changes to promote the development and growth of
breast cancers. Because estrogenic hormones act via the estrogen receptors (ERs), ER-α …