During glioblastoma surgery, delineation of the brain tumor margins is difficult because the
infiltrated and normal tissues have the same visual appearance. We use a fiber-optical …

A key challenge of central nervous system tumor surgery is to discriminate between brain
regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of …

Fluorescence spectroscopy of the endogenous emission of brain tumors has been
researched as a potentially important method for the intraoperative localization of brain …

Delineating tumor margins as accurately as possible is of primordial importance in surgical
oncology: extent of resection is associated with survival but respect of healthy surrounding …

We report the development of a compact point-detection fluorescence spectroscopy system
and two data analysis methods to quantify the intrinsic fluorescence redox ratio and …

OBJECTIVE: Adult gliomas have indistinct borders. As the ratio of neoplastic cells to normal
cells becomes lower, the ability to detect these cells diminishes. We describe a device …

Fluorescence spectroscopy of the endogenous emission of brain tumors has been
researched as a potentially important method for the intraoperative localization of brain …

The highly malignant brain tumor, glioblastoma multiforme, is difficult to totally resect without
aid due to its infiltrative way of growing and its morphological similarities to surrounding …

The primary therapeutic approach for high-grade brain tumor is surgical resection. However,
identifying tumor margins in vivo remains a major challenge. Biopsy analysis remains the …

Glioma itself accounts for 80% of all malignant primary brain tumors, and glioblastoma
multiforme (GBM) accounts for 55% of such tumors. Diffuse reflectance and fluorescence …