Purification of islets based on the physical differences in density between exocrine and islet
tissue reduces islet yields and remains one of the factors limiting islet transplantation …

Immunomagnetic cell separation has been shown to be a highly attractive alternative to
density-dependent methods for islet purification. There are two types of beads, magnetic …

Islets were selectively isolated from rat pancreatic digests using magnetic microspheres
coated with anti‐islet monoclonal antibodies. The isolation process was optimized as a …

Islet transplantation is emerging as a treatment option for selected patients with type 1
diabetes. Inconsistent isolation, purification, and recovery of large numbers of high-quality …

A simple, rapid method of islet purification is important in large-scale human islet isolation.
We have previously identified monoclonal antibodies specific for acinar cells, but not islets …

INTRODUCTION: Despite significant advances, widespread applicability of islet cell
transplantation remains elusive. Refinement of current islet isolation protocols may improve …

Islet transplantation (ITx) is an emerging and promising therapy for patients with
uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure …

For successful human pancreatic islet transplantation it remains an elusive goal to solve the
problems of quantity, purity, and viability (Hering, Bretzel and Federlin 1989). Thus …

Because successful human islet transplantation requires large quantities of viable islets that
must be separated from the highly immunogenic exocrine tissue and because handpicking …

Low yield and insufficient purity limit the transplantation of human islets of Langerhans. In
the rat, a new technique to isolate the islets of Langerhans was developed by intraarterial …