Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus

CX Yi, J van der Vliet, J Dai, G Yin, L Ru… - Endocrinology, 2006 - academic.oup.com
The arcuate nucleus (ARC) is crucial for the maintenance of energy homeostasis as an
integrator of long-and short-term hunger and satiety signals. The expression of receptors for …

Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis

A Caron, D Richard - Annals of the New York Academy of …, 2017 - Wiley Online Library
With the still‐growing prevalence of obesity worldwide, major efforts are made to understand
the various behavioral, environmental, and genetic factors that promote excess fat gain …

Brain circuits regulating energy homeostasis

TL Horvath, S Diano, M Tschöp - The Neuroscientist, 2004 - journals.sagepub.com
For decades, increasingly sophisticated methods have been designed to address the
problem of the involvement of the brain in the physiology of energy homeostasis and the …

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

SD Jordan, AC Könner, JC Brüning - Cellular and molecular life sciences, 2010 - Springer
The central nervous system (CNS) is capable of gathering information on the body's
nutritional state and it implements appropriate behavioral and metabolic responses to …

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

N Chen, H Sugihara, J Kim, Z Fu, B Barak, M Sur… - Elife, 2016 - elifesciences.org
Multiple hypothalamic neuronal populations that regulate energy balance have been
identified. Although hypothalamic glia exist in abundance and form intimate structural …

Altered hypothalamic function in diet-induced obesity

LA Velloso, MW Schwartz - International journal of obesity, 2011 - nature.com
Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic
neurons that transduce hormonal, nutrient and neuronal signals into responses that …

[HTML][HTML] Hormonal regulation of food intake

S Stanley, K Wynne, B McGowan… - Physiological …, 2005 - journals.physiology.org
Our knowledge of the physiological systems controlling energy homeostasis has increased
dramatically over the last decade. The roles of peripheral signals from adipose tissue …

Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes

F Kreier, YS Kap, TC Mettenleiter… - …, 2006 - academic.oup.com
The hypothalamus uses hormones and the autonomic nervous system to balance energy
fluxes in the body. Here we show that the autonomic nervous system has a distinct …

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice

DEG McNay, N Briançon, MV Kokoeva… - The Journal of …, 2012 - Am Soc Clin Investig
In the CNS, the hypothalamic arcuate nucleus (ARN) energy-balance circuit plays a key role
in regulating body weight. Recent studies have shown that neurogenesis occurs in the adult …

The hardship of obesity: a soft-wired hypothalamus

TL Horvath - Nature neuroscience, 2005 - nature.com
Food intake and energy expenditure are determinants of metabolic phenotype and are
regulated by the CNS. Although humans have a well-balanced homeostatic feedback loop …