Accumulated evidence from genetic animal models suggests that the brain, particularly the
hypothalamus, has a key role in the homeostatic regulation of energy and glucose …

Body weight is determined by a balance between food intake and energy expenditure.
Multiple neural circuits in the brain have evolved to process information about food, food …

Obesity and type 2 diabetes mellitus (T2DM)—disorders of energy homeostasis and glucose
homeostasis, respectively—are tightly linked and the incidences of both conditions are …

Obesity is a major public health problem associated with morbidity and mortality and
continues to increase worldwide. This review focuses on the regions of the brain that are …

Appetite is regulated by a complex system of central and peripheral signals which interact in
order to modulate the individual response to nutrient ingestion. Peripheral regulation …

Body weight is tightly controlled in a species-specific range from insects to vertebrates and
organisms have developed a complex regulatory network in order to avoid either excessive …

Interest in the control of feeding has increased as a result of the obesity epidemic and rising
incidence of metabolic diseases. The brain detects alterations in energy stores and triggers …

THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

The current obesity epidemic faces a lack of mechanistic insights. It is known that the acute
activity changes of a growing number of brain neurons rapidly alter feeding behaviour; …

The hypothalamic feeding-center model, articulated in the 1950s, held that the
hypothalamus contains the interoceptors sensitive to blood-borne correlates of available or …