The stimulatory heterotrimeric G s protein alpha subunit (G s α) is a ubiquitous guanine
nucleotide-binding protein that regulates the intracellular cAMP signaling pathway and …

A high cyclic adenosine monophosphate (cAMP) level in fully-grown immature oocytes
prevents meiotic resumption. In Xenopus, inhibitory cAMP is synthesized within oocytes …

In nearly every vertebrate species, elevated intracellular cAMP maintains oocytes in
prophase I of meiosis. Prior to ovulation, gonadotropins trigger various intra-ovarian …

Regulator of G-protein signalling 2 (Rgs2) is involved in G-protein-mediated signalling by
negatively regulating the activity of the G-protein α-subunit. In the present study, the …

Progesterone‐induced oocyte maturation is thought to involve the inhibition of an oocyte
adenylyl cyclase and reduction of intracellular cAMP. Our previous studies demonstrated …

In mammalian oocytes, the maintenance of meiotic prophase I arrest prior to the surge of LH
that stimulates meiotic maturation depends on a high level of cAMP within the oocyte. In …

Progesterone, produced by follicular cells, induces Xenopus laevis oocyte maturation
through a very early event that inhibits the activity of the adenylyl cyclase effector system …

The arrest of meiotic prophase in mouse oocytes within antral follicles requires the G protein
Gs and an orphan member of the G protein–coupled receptor family, GPR3. To determine …

The maintenance of meiotic prophase arrest in fully grown vertebrate oocytes depends on
the activity of a Gs G-protein that activates adenylyl cyclase and elevates cAMP, and in the …

During oocyte maturation, capacity and sensitivity of Ca2+ signaling machinery increases
dramatically, preparing the metaphase II (MII)-arrested egg for fertilization. Upon sperm-egg …