BACKGROUND Heterotrimeric G proteins take part in membrane-mediated cell signalling
and have a role in hormonal regulation. This study clarifies the expression and localization …

In this study, we investigated a gene-edited (Zp2 MT/MT) rat model of infertility caused by the
failure to express the zona pellucida glycoprotein 2 (ZP2) due to the significant reduction of …

Establishment of an active dialogue between the maternal endometrium and the implanting
blastocyst is essential for successful implantation. The aim of this study was to identify genes …

The heterotrimeric G-protein pathway controls numerous cellular processes, including
proliferation, differentiation, migration, membrane trafficking, and embryonic development …

High mitochondrial oxidative phosphorylation (mt-OXPHOS) levels are required to supply
the ATP necessary for follicle-stimulating hormone (FSH)-induced granulosa cell …

In mammals, a finite population of oocytes is generated during embryogenesis, and proper
oocyte meiotic divisions are crucial for fertility. Sperm-associated antigen 1 (SPAG-1) has …

Embryonic development is initiated after the fertilizing sperm contacts the egg and triggers a
process termed “egg activation,” resulting in calcium release, cortical granule exocytosis …

The ovary plays a crucial role in the reproductive system of female animals. Ovarian
problems such as ovarian insufficiency, premature aging, polycystic ovary syndrome, and …

Ovarian reserve is a key factor in the reproductive function of the ovaries. Ovarian aging is
characterized by a gradual decline in the quantity and quality of follicles. The underlying …

In mammalian growing follicles, oocytes are arrested at the diplotene stage (which
resembles the G2/M boundary in mitosis), while the granulosa cells (GCs) continue to …