Background Progranulin gene (GRN) mutations are major causes of frontotemporal lobar
degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very …

Mutations in the progranulin (GRN) gene represent about 5–10% of frontotemporal lobar
degeneration (FTLD). We describe a proband with a novel GRN mutation c. 687T> A …

GRN null mutations are among the main genetic causes of frontotemporal dementia through
progranulin haploinsufficiency. Most missense mutations are considered not pathogenic …

Progranulin gene (GRN) mutations are among the leading causes of frontotemporal lobar
degeneration, a group of neurodegenerative diseases characterized by remarkable clinical …

Background: Mutations in the GRN gene are causative for an autosomal dominant form of
frontotemporal dementia. Objective/Methods: The objective of the present study is to …

Gene coding for progranulin, GRN, is a major gene linked to frontotemporal lobar
degeneration. While most of pathogenic GRN mutations are null mutations leading to …

Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar
degeneration (FTLD). Most known GRN mutations are null mutations, such as nonsense and …

Progranulin (GRN) mutations are a major cause of frontotemporal dementia (FTD); the
spectrum of clinical phenotypes of FTD is much more extensive than previously reported …

Mutations in progranulin gene (GRN) are a common cause of autosomal dominant
frontotemporal lobar degeneration and are associated with a wide phenotypic …

Frontotemporal lobar degeneration (FTLD) is a very heterogeneous disorder. It is genetically
linked to three major genes: microtubule-associated protein tau (MAPT), progranulin (GRN) …