The endothelial nitric oxide synthase (eNOS) signaling pathway in endothelial cells has
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis.
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …

Angiogenesis, the formation of new blood capillaries from pre-existing vessels, is a hallmark
of cancer. Thus far, strategies for reducing tumor angiogenesis have focused on inhibiting …

VEGF signaling through VEGFR2 is a central regulator of the angiogenic response.
Inhibition of VEGF signaling by the stress-induced matricellular protein TSP1 plays a role in …

Multiple promoters and inhibitors mediate angiogenesis, the formation of new blood vessels,
and these factors represent potential targets for impeding vessel growth in tumors. Vascular …

Tumor angiogenesis is regulated by pro-and anti-angiogenic factors. Anti-angiogenic agents
target the interconnected network of angiogenic factors to inhibit neovascularization, which …

Tumors exploit angiogenesis, the formation of new blood vessels from pre-existing
vasculature, in order to obtain nutrients required for continued growth and proliferation …

Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, whose effect
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …

Hypoxia is an important physiological stress signal that drives angiogenesis, the formation of
new blood vessels. Besides an increase in the production of pro-angiogenic signals such as …

Tumor growth and progression are critically dependent on the establishment of a vascular
support system. This is often accomplished via the expression of pro-angiogenic growth …