[HTML][HTML] Mathematical model predicts effective strategies to inhibit VEGF-eNOS signaling
The endothelial nitric oxide synthase (eNOS) signaling pathway in endothelial cells has
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …
[HTML][HTML] Computer simulation of TSP1 inhibition of VEGF–akt–eNOS: an angiogenesis triple threat
The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis.
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …
[HTML][HTML] Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue
JA Rohrs, CD Sulistio, SD Finley - NPJ systems biology and …, 2016 - nature.com
Angiogenesis, the formation of new blood capillaries from pre-existing vessels, is a hallmark
of cancer. Thus far, strategies for reducing tumor angiogenesis have focused on inhibiting …
of cancer. Thus far, strategies for reducing tumor angiogenesis have focused on inhibiting …
[HTML][HTML] Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
H Bazzazi, JS Isenberg, AS Popel - Frontiers in physiology, 2017 - frontiersin.org
VEGF signaling through VEGFR2 is a central regulator of the angiogenic response.
Inhibition of VEGF signaling by the stress-induced matricellular protein TSP1 plays a role in …
Inhibition of VEGF signaling by the stress-induced matricellular protein TSP1 plays a role in …
The impact of tumor receptor heterogeneity on the response to anti-angiogenic cancer treatment
Multiple promoters and inhibitors mediate angiogenesis, the formation of new blood vessels,
and these factors represent potential targets for impeding vessel growth in tumors. Vascular …
and these factors represent potential targets for impeding vessel growth in tumors. Vascular …
[HTML][HTML] Exploring the extracellular regulation of the tumor angiogenic interaction network using a systems biology model
Tumor angiogenesis is regulated by pro-and anti-angiogenic factors. Anti-angiogenic agents
target the interconnected network of angiogenic factors to inhibit neovascularization, which …
target the interconnected network of angiogenic factors to inhibit neovascularization, which …
[HTML][HTML] Mechanistic modeling quantifies the influence of tumor growth kinetics on the response to anti-angiogenic treatment
TD Gaddy, Q Wu, AD Arnheim… - PLoS computational …, 2017 - journals.plos.org
Tumors exploit angiogenesis, the formation of new blood vessels from pre-existing
vasculature, in order to obtain nutrients required for continued growth and proliferation …
vasculature, in order to obtain nutrients required for continued growth and proliferation …
Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, whose effect
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
[HTML][HTML] Transcriptional and post-transcriptional regulation of thrombospondin-1 expression: a computational model
C Zhao, JS Isenberg, AS Popel - PLoS computational biology, 2017 - journals.plos.org
Hypoxia is an important physiological stress signal that drives angiogenesis, the formation of
new blood vessels. Besides an increase in the production of pro-angiogenic signals such as …
new blood vessels. Besides an increase in the production of pro-angiogenic signals such as …
Mathematical modeling of cellular cross-talk between endothelial and tumor cells highlights counterintuitive effects of VEGF-targeted therapies
H Jain, T Jackson - Bulletin of mathematical biology, 2018 - Springer
Tumor growth and progression are critically dependent on the establishment of a vascular
support system. This is often accomplished via the expression of pro-angiogenic growth …
support system. This is often accomplished via the expression of pro-angiogenic growth …