Aldosterone, the principal human mineralocorticoid, acts mainly for sodium reabsorption
with potassium and hydrogen excretion. The adrenal cortex is the main site of aldosterone …

Several polymorphisms in genes of the renin-angiotensin-aldosterone system have been
found to have pleiotropic effects on cardiovascular disorders. Recently, a polymorphism …

Aldosterone plays an important role in the regulation of electrolyte and water homeostasis
and in blood pressure maintenance. The latest studies have revealed involvement of this …

In addition to regulating renal sodium resorption and, thus, intravascular volume,
aldosterone may have direct effects on the cardiovascular system. We previously identified a …

Left ventricular remodeling after myocardial infarction involves activation of the renin-
angiotensin-aldosterone system. Recently, the biallelic− 344T/C polymorphism of the …

In addition to regulating renal sodium resorption and, thus, intravascular volume,
aldosterone may have direct effects on the cardiovascular system. We previously identified a …

Background—The− 344C allele of a 2-allele (C or T) polymorphism in the promoter of the
gene encoding aldosterone synthase (CYP11B2) is associated with increased left …

Objective Several recent studies have shown that the aldosterone synthase gene
(CYP11B2)− 344C/T polymorphism is related to cardiovascular diseases. However, whether …

Introduction: The tissue renin-angiotensin system is implicated in the pathogenesis of
coronary artery disease (CAD). As locally synthesised aldosterone is a potential mediator of …

OBJECTIVES: Aldosterone synthase produces aldosterone, which regulates electrolytes
and thereby blood pressure. Polymorphisms in aldosterone-synthase gene (CYP11B2) may …