The retinoblastoma protein RB and the transcription factor p53 are central tumor
suppressors. They are often found inactivated in various tumor types. Both proteins play …

Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of
p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent …

Most human cancers acquire mutations causing defects in the p53 signaling pathway. The
tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for …

The control of cellular proliferation is key in the proper development of a complex organism,
the maintenance of tissue homeostasis, and the ability to respond to various hormonal and …

The retinoblastoma protein (pRb) is one of the key cell-cycle regulating proteins and its
inactivation leads to neoplastic transformation and carcinogenesis. This protein regulates …

The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well
known as a negative regulator of the cell cycle through its ability to bind the transcription …

The retinoblastoma protein (pRB) can both positively and negatively regulate transcription.
The former correlates with its ability to promote differentiation and the latter with its ability to …

The tumor suppressor p53 plays an important role in cell cycle arrest by downregulating
transcription. Many genes repressed by p53 code for proteins with functions in G₂/M. A …

The life history of cancer cells encompasses a series of genetic missteps in which normal
cells are progressively transformed into tumor cells that invade surrounding tissues and …

Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the
retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription …