Intercellular communication allows the co-ordination of cell metabolism between tissues as
well as sensitivity to extracellular stimuli. Paracrine stimulation and cell-to-cell coupling …

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …

Abstract Connexin 43 (Cx43)-mediated gap junction intercellular communication (GJIC)
plays a crucial role in the pathology and physiology of joint tissues. Transforming growth …

Articular cartilage consists of hyaline cartilage, is a major constituent of the human
musculoskeletal system and has critical functions in frictionless joint movement and articular …

Background Recent work has shown that the gap junction protein connexin43 (Cx43) is
upregulated in cells of the joint during osteoarthritis (OA). Here we examined if the OA …

Publisher Summary This chapter reviews the role of direct cell–cell interactions in the
development and remodeling of the skeletal tissue, and focuses on the cell–cell adhesion …

Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and
possess a highly differentiated phenotype that is the hallmark of the unique physiological …

Intercellular communication through gap junctions allows tissue coordination of cell
metabolism and sensitivity to extracellular stimuli. Intercellular Ca2+ signaling was …

The role of gap junctions, particularly that of connexin43 (Cx43), has become an area of
increasing interest in bone physiology. An abundance of studies have shown that Cx43 …

Receptor activator of NF‐κB ligand (RANKL) is crucial in osteoclastogenesis but signaling
events involved in osteoclast differentiation are far from complete and other signals may play …