The regeneration and repair of cartilage damaged by injury or disease, a major goal of
orthopaedic science, depends on understanding the structure and function of both the …

An improved understanding of fundamental physiological principles and progressive
pathophysiological processes in human articular joints (eg, shoulders, knees, elbows) …

Articular cartilage is a tissue designed to withstand compression during joint movement and,
in vivo, is subjected to a wide range of mechanical loading forces. Mechanosensitivity has …

Osteocytes present in the bone are known to be the major mechanosensory cells. Their
involvement in mechanoregulation of bone remodeling is not yet clear. Osteocytes are …

The cytoplasmic C‐terminus of connexin43 (Cx43) interacts with numerous signaling
complexes. We hypothesize that signal complex docking to the Cx43 C‐terminus (CT) is …

Osteocytes are thought to be mechanosensory cells that respond to mechanical stress by
sending signals to other bone cells to initiate bone remodeling. An osteocyte‐like cell line …

Fig. 1. The mechanostat theory. The mechanostat is comprised of mechanisms that sense
load-induced signals, activators to remodel bone appropriately, and a set point (s). Adapted …

Chondrocytes are effectively involved in the pathophysiological processes of inflammation in
joints. They form cellular processes in the superficial layer of the articular cartilage and form …

There is increasing evidence that osteocytes regulate multiple aspects of bone remodeling
through bi‐directional communication with osteoblasts. This is potentially mediated through …

Purpose Osteocyte network structure correlates with bone material quality. This network is
profoundly altered in diabetic mice; however, the underlying mechanisms are unknown. The …