CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in
MS pathogenesis remains poorly defined. Although myelin proteins are considered potential …

Patients with multiple sclerosis (MS) display significant peripheral blood CD8+ T cell
receptor biases, suggesting clonal selection. Our objective was to identify relevant myelin …

Multiple sclerosis (MS) is an autoimmune disease in which myelin-specific T cells are
believed to play a crucial pathogenic role. Nevertheless, so far it has been extremely difficult …

Objective Maintenance therapy with anti-CD25 antibody has emerged as a potentially useful
treatment for multiple sclerosis (MS). Constitutive CD25 expression on CD4+ CD25+ …

With the discovery that the highly effective anti-CD20 antibody therapies developed to
deplete CD20+ B cells deplete CD20+ T cells equally well, a great interest in the biological …

An aberrant immune activation is believed to be important in the pathogenesis of multiple
sclerosis (MS). Expression of CD4+ T lymphocyte surface molecules indicative of immune …

Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis
(MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4+ …

Although multiple sclerosis (MS) patients and healthy individuals have similar frequencies of
myelin basic protein (MBP)-specific T cells, the activation state of these cells has not been …

Multiple lines of evidence suggest that CD4+ lymphocytes initiate autoimmune responses
against myelin antigens in multiple sclerosis (MS). The increased frequency of activated …

A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after
starting anti-CD20 therapy. This activity does not recur with further dosing, possibly reflecting …