Background Efficient gene transfer is a major challenge for non‐viral gene therapy.
Understanding how non‐viral vectors initiate gene expression could lead to the …

Background Nonviral vectors based on polyethylenimine (PEI) usually contain an excess of
PEI that is not complexed to DNA. Since unbound PEI contributes to cellular and systemic …

Since the first published examination of poly (ethylenimine)(PEI) as a gene delivery vehicle,
there has been a flurry of research aimed at this polycation and its role in gene therapy …

Polyethylenimine (PEI) is a cationic polymer capable of delivering DNA molecules into
cultured mammalian cells as charge complexes. The application of PEI polyplexes in gene …

The polycation polyethylenimine (PEI) has recently been widely employed for the design of
DNA delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

Branched and linear polyethylenimines (PEIs) are proving to be efficient, non-toxic and
versatile agents for in vivo gene delivery by a number of routes. A major factor in the …

The continually increasing wealth of knowledge about the role of genes involved in acquired
or hereditary diseases renders the delivery of regulatory genes or nucleic acids into affected …

We have developed a modified poly (ethylenimine)(PEI) transfection procedure that
significantly increases PEI's transfection efficiency. While the basic transfection procedure …

Polyethylenimine (PEI) is a polycation with potential application as a nonviral vector for gene
delivery. Here we show that after conjugation with homobifunctional amine reactive …

Poly (ethylenimine)(PEI) is one of a number of polycations that has been used successfully
to transfer genes into living cells. Although PEI shows promise in the field of gene therapy, to …