Background: Erythropoietin (Epo) and vascular endothelial growth factor (VEGF) are two
vasoactive molecules with essential trophic effects for brain development. The expression …

The tissue protective functions of the hematopoietic growth factor erythropoietin (EPO) are
independent of its action on erythropoiesis. EPO and its receptors (EPOR) are expressed in …

Acute stroke is one of the major causes of death and disabilities. Since the 1980s many
clinical studies have been conducted to evaluate neuroprotective approaches to treat this …

Numerous studies explored the therapeutic effects of erythropoietin (EPO) on
neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of …

Purpose: To provide an overview of the current knowledge on neuroprotective properties of
Erythropoietin (Epo), mechanisms by which Epo produces neuroprotection, and signaling …

Our common home, planet Earth, is inhabited by more than 7 billion human beings. The
average life expectancy currently estimated for men is~ 69 years, with strong differences …

Erythropoietin (EPO) is a cytokine mainly induced in hypoxia conditions. Its major production
site is the kidney. EPO primarily acts on the erythroid progenitor cells in the bone marrow …

Background and Purpose—Erythropoietin (EPO) promotes proliferation and differentiation of
erythroid progenitors and the survival of maturing erythroid cells. Here, we investigated the …

Erythropoietin (EPO) is one of the most successful biopharmaceuticals in history and is used
for treating anemia of different origins. However, it became clear that EPO could also work in …

Two hematopoietic cytokines are currently gaining increasing attention within neurological
research. Erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) have long …