Rationale: Asymmetrical lung injury is a frequent clinical presentation. Regional distribution
of Vt and positive end-expiratory pressure (PEEP) could result in hyperinflation of the less …

Rationale: The physiological basis of lung protection and the impact of positive end-
expiratory pressure (PEEP) during pronation in acute respiratory distress syndrome are not …

Rationale: Esophageal manometry is the clinically available method to estimate pleural
pressure, thus enabling calculation of transpulmonary pressure (Pl). However, many …

Objective: Recent interest has arisen in airway driving pressure (DP AW), the quotient of
tidal volume (VT), and respiratory system compliance (C RS), which could serve as a direct …

Positive end-expiratory pressure (PEEP), by increasing lung volume in acute lung injury,
may recruit terminal air spaces in the involved regions, but may also distend noninvolved …

Background Lung failure after acute lung injury remains a challenge in different clinical
settings. Various interventions for restoration of gas exchange have been investigated …

The goal of this study was to assess lung morphology in patients with acute lung injury
according to the presence or the absence of a lower inflection point (LIP) on the lung …

Among mechanically ventilated patients, asymmetrical lung injury is probably extremely
frequent in the intensive care unit but the lack of standardized measurements does not allow …

Acute lung injury can be worsened by inappropriate mechanical ventilation, and numerous
experimental studies suggest that ventilator-induced lung injury is increased by excessive …

We aimed to elucidate the relationships between pleural (Ppl), esophageal (Pes), and
superimposed gravitational pressures in acute lung injury, and to understand the …