Objective Epilepsy is a neurologically based disease. Literature data indicate a certain
association between the polymorphism of these genes, which participate in the metabolism …

Abstract Background and Objective Despite the availability of several antiepileptic drugs,
drug resistance remains one of the major challenges in epilepsy therapy. Genetic factors are …

Background Identified the polymorphisms of CYP2D6, CYP2C9, CYP2C19 and CYP3A4,
within a rigorously selected population of pediatric patients with drug-resistant epilepsy …

Cytochrome (CYP) P450 enzymes are responsible for metabolism of antiepileptic drugs
(AEDs), and encoded by highly polymorphic genes. A case–control study was conducted in …

Methods: A total of 402 patients with epilepsy were enrolled in this study; 128 were drug
resistant and 274 were drug responsive. The peripheral blood samples of the patients with …

Abstract Background The cytochrome P450 (CYP) isoenzymes have an indispensable role
in the metabolic phase of different medications during the treatment of multiple …

Drug‐resistant epilepsies still remain one of the most profound problems of contemporary
epileptology. Several mechanisms of drug resistance are possible; among them, genetic …

Epilepsy is a major global issue. Epilepsy patients are treated with AED (antiepileptic drugs).
Interindividual variability in drug response has been documented in several studies. The …

OBJECTIVE: CYP2C9 is a major enzyme in human drug metabolism and the polymorphism
observed in the corresponding gene may affect therapeutic outcome during treatment. The …

Background A total of 50 million persons were diagnosed worldwide with epilepsy. One-third
of them are experiencing debilitating seizures despite optimum anti‐epileptic drugs (AEDs) …