Background and aims A relationship between treatment outcomes and intestinal microbiota
in patients with inflammatory bowel diseases has been demonstrated. Cyclosporine …

Butyrate, a short chain fatty acid (SCFA) produced by bacterial fermentation of undigested
carbohydrates in the colon, constitutes the major fuel for colonocytes. We have earlier …

Objective Inflammatory bowel disease (IBD) is a disorder intestinal inflammation and
impaired barrier function, associated with increased epithelial expression of …

Somatostatin (SST), an important neuropeptide of the gastrointestinal tract has been shown
to stimulate sodium chloride absorption and inhibit chloride secretion in the intestine …

Monocarboxylate transporter isoform-1 (MCT1) plays an important role in the absorption of
short-chain fatty acids (SCFAs) in the colon. Butyrate, a major SCFA, serves as the primary …

Cyclophosphamide (CTX) is widely used in cancer chemotherapy, but it often induces
mucositis, in which the disruption of the gut microbiota might play a pivotal role. Whether the …

Background & Aims: Butyrate serves as the major source of energy for colonic epithelial
cells, and has profound effects on their proliferation, differentiation, and apoptosis. Transport …

Background & Aims: Butyrate oxidation is impaired in intestinal mucosa of patients with
inflammatory bowel diseases (IBD). Butyrate uptake by colonocytes involves the …

Butyrate, a key short-chain fatty acid metabolite of colonic luminal bacterial action on dietary
fiber, serves as a primary fuel for the colonocytes, ameliorates mucosal inflammation, and …

Butyrate (BT) is one of the main end products of anaerobic bacterial fermentation of dietary
fiber within the human colon. Among its recognized effects, BT inhibits colon carcinogenesis …