Background Asthma exacerbations cause lung hyperinflation, elevation in load to inspiratory
muscles, and decreased breathing capacity that, in severe cases, may lead to inspiratory …

The effects of a deep inspiration (DI) in individuals with asthma differ from those observed in
healthy subjects. It has been postulated that the beneficial effect of lung inflation is mediated …

Airways distend with each inspiration, while a sigh or deep inspiration (DI) leads to a
significant or a maximum distension of the airways. Distension of the airways is thought to …

Although airway patency is partially maintained by parenchymal tethering, this structural
support is often ignored in many discussions of asthma. However, agonists that induce …

Background and objective The reduction of forced expiratory volume in 1 s (FEV1) in
response to methacholine challenge in asthma may reflect two components: airway …

Background Studies suggest that the increased volume of both abdominal and rib cage
compartments of the chest wall contribute to dyspnea during methacholine-induced airway …

Airway obstruction in asthma and chronic obstructive pulmonary disease (COPD) is often
associated with lung hyperinflation. In this review, we examine the mechanisms that may …

Lung inflation has been shown to dilate airways by altering the mechanical equilibrium
between opposing airway and parenchymal forces. However, it is not known how …

Background and objective Obesity produces restrictive effects on lung function. We
previously reported that obese patients with asthma exhibit a propensity towards small …

Background In asthma, inflammation affects both the proximal and distal airways and may
induce significant hyperinflation (HI). This study sought to evaluate the prevalence of HI in …