Communication between osteoblasts, osteoclasts, and osteocytes is integral to their ability to
build and maintain the skeletal system and respond to physical signals. Various …

Physical signals, in particular mechanical loading, are clearly important regulators of bone
turnover. Indeed, the structural success of the skeleton is due in large part to the bone's …

Gap junctions formed by connexins (Cx) play an important role in transmitting signals
between bone cells such as osteoblasts and osteoclasts, cells responsible for bone …

The cooperative nature of bone remodeling requires efficient means of intercellular
recognition, adhesion, and communication that allow cells to sort and migrate, synchronize …

Gap junctional intercellular communication (GJIC) mediated by connexins, in particular
connexin 43 (Cx43), plays important roles in regulating signal transmission among different …

Aging demonstrates deleterious effects upon the skeleton which can predispose an
individual to osteoporosis and related fractures. Despite the well‐documented evidence that …

Osteoblasts participate in both bone formation through the synthesis of extracellular matrix
and osteoclast differentiation through the expression of osteoclast differentiation factor …

Previous research has shown that bone-resorbing osteoclasts contain connexin molecules
that organize to hemichannel-forming connexons, which in turn form functional gap junctions …

Cell-to-cell and cell-to-matrix communication in bone cells mediated by gap junctions and
hemichannels, respectively, maintains bone homeostasis. Gap junctional communication …

Gap junctions (GJs) formed by connexins (Cxs) play an important role in the intercellular
communication within most body tissues. In this paper, we focus on GJs and Cxs present in …