Background Currently, there is limited knowledge regarding which imaging assessments of
asthma are associated with accelerated longitudinal decline in lung function. Objectives We …

Background To prospectively apply an automated, quantitative three-dimensional approach
to imaging and airway analysis to assess airway remodeling in asthma patients. Methods …

Rationale and Objectives Previous cross-sectional studies have demonstrated that airway
wall thickness and air trapping are greater in subjects with severe asthma than in those with …

Background Severe asthma is a heterogeneous condition. Airway remodelling is a feature of
severe asthma and can be determined by the assessment of high-resolution computed …

Background Asthma heterogeneity is multidimensional and requires additional tools to
unravel its complexity. Computed tomography (CT)–assessed proximal airway remodeling …

Background A recent study demonstrated a significant correlation between bronchial biopsy
airway remodeling and quantitative computed tomography looking at bronchial wall …

Airway remodeling is an established feature of asthma. Histologic examination is essential
in the assessment of remodeling that is a pathologic concept. Examinations of autopsied or …

Background Imaging variables, including airway diameter, wall thickness, and air trapping,
have been found to be important metrics when differentiating patients with severe asthma …

Background Clustering key clinical characteristics of participants in the Severe Asthma
Research Program (SARP), a large, multicenter prospective observational study of patients …

Despite advances in CT imaging techniques, there is an urgent need for both proof-of-
concept studies and large cross-sectional and longitudinal clinical trials in severe asthma to …