Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations

J Sun, BL Chang, SD Isaacs, KE Wiley, F Wiklund… - The …, 2008 - Wiley Online Library
BACKGROUND A strong cumulative effect of five genetic variants and family history on
prostate cancer risk was recently reported in a Swedish population (CAPS). We carried out …

Sequence variants at 22q13 are associated with prostate cancer risk

J Sun, SL Zheng, F Wiklund, SD Isaacs, G Li, KE Wiley… - Cancer research, 2009 - AACR
To search for genetic variants that are associated with prostate cancer risk in the genome,
we combined the data from our genome-wide association study (GWAS) in a population …

Estimation of absolute risk for prostate cancer using genetic markers and family history

J Xu, J Sun, AK Kader, S Lindström, F Wiklund… - The …, 2009 - Wiley Online Library
BACKGROUND Multiple DNA sequence variants in the form of single‐nucleotide
polymorphisms (SNPs) have been found to be reproducibly associated with prostate cancer …

Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk

BT Helfand, AJ Fought, S Loeb, JJ Meeks, D Kan… - The Journal of …, 2010 - Elsevier
PURPOSE: Five genetic variants along chromosomes 8q24 and 17q have a cumulative
association with prostate cancer risk. Our research group previously reported an association …

Replication of prostate cancer risk loci in a Japanese case–control association study

H Yamada, KL Penney, H Takahashi… - Journal of the …, 2009 - academic.oup.com
Background Two prostate cancer genome-wide scans in populations of European ancestry
identified several genetic variants that are strongly associated with prostate cancer risk. The …

Risk analysis of prostate cancer in PRACTICAL, a multinational consortium, using 25 known prostate cancer susceptibility loci

A Amin Al Olama, S Benlloch, AC Antoniou… - … , biomarkers & prevention, 2015 - AACR
Background: Genome-wide association studies have identified multiple genetic variants
associated with prostate cancer risk which explain a substantial proportion of familial relative …

Cumulative association of five genetic variants with prostate cancer

SL Zheng, J Sun, F Wiklund, S Smith… - … England Journal of …, 2008 - Mass Medical Soc
Background Single-nucleotide polymorphisms (SNPs) in five chromosomal regions—three
at 8q24 and one each at 17q12 and 17q24. 3—have been associated with prostate cancer …

Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium

Z Kote-Jarai, DF Easton, JL Stanford… - … Biomarkers & Prevention, 2008 - AACR
A recent genome-wide association study found that genetic variants on chromosomes 3, 6,
7, 10, 11, 19 and X were associated with prostate cancer risk. We evaluated the most …

Evaluation of a multiethnic polygenic risk score model for prostate cancer

A Plym, KL Penney, S Kalia, P Kraft… - JNCI: Journal of the …, 2022 - academic.oup.com
Polygenic risk scores (PRSs) of common genetic variants have shown promise in prostate
cancer risk stratification, but their validity across populations has yet to be confirmed. We …

Association of prostate cancer risk loci with disease aggressiveness and prostate cancer–specific mortality

MM Pomerantz, L Werner, W Xie, MM Regan… - Cancer prevention …, 2011 - AACR
Genome-wide association studies have detected more than 30 inherited prostate cancer risk
variants. While clearly associated with risk, their relationship with clinical outcome …