[HTML][HTML] Adaptive immunity in pulmonary sarcoidosis and chronic beryllium disease

SA Greaves, SM Atif, AP Fontenot - Frontiers in immunology, 2020 - frontiersin.org
Pulmonary sarcoidosis and chronic beryllium disease (CBD) are inflammatory
granulomatous lung diseases defined by the presence of non-caseating granulomas in the …

Identification of multiple public TCR repertoires in chronic beryllium disease

NA Bowerman, MT Falta, DG Mack… - The Journal of …, 2014 - journals.aai.org
Chronic beryllium disease (CBD) is a granulomatous lung disease characterized by the
accumulation of beryllium (Be)-specific CD4+ T cells in bronchoalveolar lavage. These …

Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis

L Li, LJ Silveira, N Hamzeh, M Gillespie… - European …, 2016 - Eur Respiratory Soc
A subset of beryllium-exposed workers develop beryllium sensitisation (BeS) which
precedes chronic beryllium disease (CBD). We conducted an in-depth analysis of …

Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease

DG Mack, MT Falta, AS McKee… - Proceedings of the …, 2014 - National Acad Sciences
Susceptibility to chronic beryllium disease (CBD) is linked to certain HLA-DP molecules,
including HLA-DP2. To elucidate the molecular basis of this association, we exposed mice …

Beryllium-Induced Tumor Necrosis Factor-α Production by CD4+ T Cells Is Mediated by HLA-DP

RT Sawyer, CE Parsons, AP Fontenot… - American journal of …, 2004 - atsjournals.org
Beryllium (Be) presentation to CD4+ T cells from patients with chronic beryllium disease
(CBD) results in T cell activation, and these Be-specific CD4+ T cells undergo clonal …

T cell recognition in chronic beryllium disease

M Amicosante, AP Fontenot - Clinical Immunology, 2006 - Elsevier
Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium
exposure in the workplace and is characterized by the accumulation of beryllium-specific …

[HTML][HTML] Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice

MT Falta, AN Tinega, DG Mack, NA Bowerman… - Mucosal …, 2016 - Elsevier
Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with
the accumulation of beryllium (Be)-specific CD4+ T cells into the lung. Genetic susceptibility …

Expansions of T-cell subsets expressing particular T-cell receptor variable regions in chronic beryllium disease

AP Fontenot, BL Kotzin, CE Comment… - American journal of …, 1998 - atsjournals.org
Chronic beryllium disease (CBD) is a granulomatous disorder characterized by the
presence of noncaseating granulomas and mononuclear cell inflammation, occurring in 1 to …

T cell recognition of beryllium

S Dai, MT Falta, NA Bowerman, AS McKee… - Current opinion in …, 2013 - Elsevier
Highlights•CBD is a classic example of a disorder resulting from a gene–environment
interaction.•HLA-DP2 is linked for the generation of beryllium-induced hypersensitivity.•HLA …

Genetic susceptibility and immune-mediated destruction in beryllium-induced disease

AP Fontenot, LA Maier - Trends in immunology, 2005 - cell.com
Chronic beryllium disease (CBD) is a hypersensitivity disorder caused by beryllium
exposure in the workplace and is characterized by the accumulation of beryllium-specific …