Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Fibrosis is the endpoint of many chronic inflammatory diseases and is defined by an
abnormal accumulation of extracellular matrix components. Despite its slow progression, it …

Most chronic diseases involving inflammation have a fibrotic component that involves
remodeling and excess accumulation of extracellular matrix components. Left unchecked …

Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in
the clinic for approximately 10 years. From animal models to clinical trials, MSCs have …

Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or
hepatocellular carcinoma (HCC) and accounting for many deaths each year. The …

Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell
niche, function to maintain tissue homeostasis and regeneration after damage. This …

Mesenchymal stem cells (MSCs) are multi-potent cells which have been widely used for
tissue regeneration and immunomodulation. The infusion of autologous and allogenic MSCs …

Recently there has been a paradigm shift in what is considered to be the therapeutic
promise of mesenchymal stem cells (MSCs) in diseases of vital organs. Originally, research …

Liver fibrosis is a common result of most chronic liver diseases, and advanced fibrosis often
leads to cirrhosis. Currently, there is no effective treatment for liver cirrhosis except liver …

Human mesenchymal stem cells (hMSCs) have tremendous promise for use in a variety of
clinical applications. The ability of these cells to self-renew and differentiate into multiple …