As an alternative to the traditional chemical synthesis or in vivo production of L-pipecolic
acid, we have developed two ex vivo strategies using purified and immobilised enzymes for …

Deficiency in petroleum resources and increasing environmental concerns have pushed a
bio-based economy to be built, employing a highly reproducible, metal contaminant free …

Pipecolic acid is an important precursor of many useful microbial secondary metabolites.
Pipecolic acid-derived moieties are often crucial for the biological activities of some …

The nonproteinogenic cyclic metabolite l-pipecolic acid is a chiral precursor for the synthesis
of various commercial drugs and functions as a cell-protective extremolyte and mediator of …

Pipecolic acid, a non-proteinogenic amino acid, is a metabolite in lysine metabolism and a
key chiral precursor in local anesthesia and macrolide antibiotics. To replace the …

Genetically engineered host bacteria have an extensive history for the production of specific
proteins including the synthesis of single enzymes for the modification of compounds …

Background The six-carbon circular non-proteinogenic compound l-pipecolic acid is an
important chiral drug intermediate with many applications in the pharmaceutical industry. In …

Corynebacterium glutamicum is used for the million‐ton scale production of amino acids and
has recently been engineered for production of the cyclic non‐proteinogenic amino acid L …

Abstract l-Pipecolic acid is a chiral pharmaceutical intermediate. An enzymatic system for the
synthesis of l-pipecolic acid from l-lysine by commercial l-lysine α-oxidase from Trichoderma …

Access to a series of 5-methylpyrrolidone derivatives is described directly using the
biosourced levulinic acid in the absence of any additive, catalyst or solvent. The highly …