Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation

AK Ziebandt, H Kusch, M Degner, S Jaglitz… - …, 2010 - Wiley Online Library
Sequencing of at least 13 Staphylococcus aureus isolates has shown that genomic plasticity
impacts significantly on the repertoire of virulence factors. However, genome sequencing …

Proteomic approaches to study Staphylococcus aureus pathogenesis

P François, A Scherl, D Hochstrasser, J Schrenzel - Journal of proteomics, 2010 - Elsevier
Staphylococcus aureus is an important human and veterinary pathogen that causes a wide
variety of infections ranging from benign skin infections to life threatening diseases …

A proteomic view of cell physiology and virulence of Staphylococcus aureus

M Hecker, D Becher, S Fuchs, S Engelmann - International Journal of …, 2010 - Elsevier
Staphylococcus aureus is a human pathogen that has advanced to a main problem in
hospital settings since effective treatment options for infections caused by this pathogen are …

[HTML][HTML] A Proteomic View of an Important Human Pathogen – Towards the Quantification of the Entire Staphylococcus aureus Proteome

D Becher, K Hempel, S Sievers, D Zühlke… - PloS one, 2009 - journals.plos.org
The genome sequence is the “blue-print of life,” but proteomics provides the link to the actual
physiology of living cells. Because of their low complexity bacteria are excellent model …

[HTML][HTML] From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

NK Priest, JK Rudkin, EJ Feil… - Nature Reviews …, 2012 - nature.com
With the advent of high-throughput whole-genome sequencing, it is now possible to
sequence a bacterial genome in a matter of hours. However, although the presence or …

[HTML][HTML] Exploring the transcriptome of Staphylococcus aureus in its natural niche

D Chaves-Moreno, ML Wos-Oxley, R Jáuregui… - Scientific reports, 2016 - nature.com
Staphylococcus aureus is an important human pathogen and commensal, where the human
nose is the predominant reservoir. To better understand its behavior in this environmental …

[HTML][HTML] A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions

S Michalik, M Depke, A Murr, M Gesell Salazar… - Scientific Reports, 2017 - nature.com
Data-independent acquisition mass spectrometry promises higher performance in terms of
quantification and reproducibility compared to data-dependent acquisition mass …

Small colony variants of Staphylococcus aureus reveal distinct protein profiles

A Kriegeskorte, S König, G Sander, A Pirkl… - …, 2011 - Wiley Online Library
Small‐colony variants (SCVs) of Staphylococcus aureus represent a slow‐growing
subpopulation causing chronic and relapsing infections due to their physiological adaptation …

Genome-Wide Analysis of Ruminant Staphylococcus aureus Reveals Diversification of the Core Genome

NL Ben Zakour, DE Sturdevant, S Even… - Journal of …, 2008 - Am Soc Microbiol
Staphylococcus aureus causes disease in humans and a wide array of animals. Of note, S.
aureus mastitis of ruminants, including cows, sheep, and goats, results in major economic …

[HTML][HTML] Towards the characterization of the hidden world of small proteins in Staphylococcus aureus, a proteogenomics approach

S Fuchs, M Kucklick, E Lehmann, A Beckmann… - PLoS …, 2021 - journals.plos.org
Small proteins play essential roles in bacterial physiology and virulence, however,
automated algorithms for genome annotation are often not yet able to accurately predict the …