Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …

The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Importance of the field: Connexins (Cxs) and gap junctional intercellular communications
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …

Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

Direct communication between cells, mediated by gap junctions, is nowadays considered as
an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap …

Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …