Gentiopicroside (Gent) is promising as an important protective secoiridoid compound
against pain. The present study was designed to investigate whether administration of Gent …

Gentiopicroside is one of the secoiridoid compound isolated from Gentiana lutea. It exhibits
analgesic activities in the mice. The anterior cingulate cortex (ACC) is a forebrain structure …

Chronic neuropathic pain poses a significant health problem worldwide, for which effective
treatment is lacking. The current work aimed to investigate the potential analgesic effect of …

Geraniol (GER) is a monoterpene alcohol with various biochemical and pharmacological
properties present in the essential oil of more than 160 species of herbs (especially the …

Abstract Context. Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae-
Caesalpinioideae) is popularly known as “caneleiro”. Previous studies showed antioxidant …

Neuropathic pain is an intractable disease with few definitive therapeutic options. Anethole
(AN) has been confirmed to possess potent anti-inflammatory and neuroprotective …

Peripheral nerve injuries often induce neuropathic pain through inflammation.
Cryptotanshinone isolated from Salvia miltiorrhiza Bunge has been found to exert anti …

Background: Evidence has been generated that various anticonvulsant agents provide relief
of several chronic pain syndromes and therefore as an alternative to opioids, nonsteroidal …

AIM OF THE STUDY: Shu-jing-huo-xue-tang (SJHXT)(Japanese name: Sokei-kakketu-to), a
traditional Chinese herbal medicine composed of 17 crude drugs, has been prescribed over …

Epidemiological studies demonstrate that pain frequently occurs comorbid with depression.
Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits …