[HTML][HTML] Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy

B Sonkodi, MD Resch, T Hortobágyi - Journal of Molecular Neuroscience, 2022 - Springer
Dry eye disease (DED) is a multifactorial disorder with recognized pathology, but not entirely
known pathomechanism. It is suggested to represent a continuum with neuropathic corneal …

Corneal nerve loss is related to the severity of painful diabetic neuropathy

A Kalteniece, M Ferdousi, S Azmi… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Previously it has been shown that patients with painful diabetic
neuropathy (PDN) have greater corneal nerve loss compared to patients with painless …

[HTML][HTML] Could contact lens dryness discomfort symptoms sometimes have a neuropathic basis?

CW McMonnies - Eye and Vision, 2021 - Springer
Symptoms of dryness discomfort in soft contact lens wearers frequently lead to
discontinuation from wear. The negative influence of pre-fitting tear dysfunctions appears …

Corneal neuropathic pain in irritable bowel syndrome: clinical findings and in vivo corneal confocal microscopy

IÇ Uçar, F Esen, SA Turhan, H Oguz… - Graefe's Archive for …, 2021 - Springer
Purpose Ocular discomfort is a common symptom in central sensitization syndromes. The
aim of this study was to evaluate ocular surface discomfort and related corneal changes in …

Corneal nerves in health and disease

BS Shaheen, M Bakir, S Jain - Survey of ophthalmology, 2014 - Elsevier
Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

Successful management of corneal neuropathic pain with intrathecal targeted drug delivery

SM Hayek, JA Sweet, JP Miller, RR Sayegh - Pain Medicine, 2016 - academic.oup.com
Objective. To describe the successful treatment of refractory corneal neuropathic pain with
neuromodulation techniques. Design. Single case report. Setting. Academic tertiary care …

[HTML][HTML] Corneal nerve abnormalities in painful dry eye disease patients

A Guerrero-Moreno, H Liang, N Moreau, J Luzu… - Biomedicines, 2021 - mdpi.com
Background: This study aimed to compare the corneal nerve structural abnormalities
detected using in vivo confocal microscopy (IVCM) in patients with neuropathic corneal pain …

The utilization of artificial intelligence for corneal nerve analyses of in vivo confocal microscopy images for the diagnosis of neuropathic corneal pain

ND Koseoglu, A Beam… - … Ophthalmology & Visual …, 2018 - iovs.arvojournals.org
Purpose: Neuropathic corneal pain (NCP) is one of the most underdiagnosed ocular surface
diseases due to lack of clinical signs explaining patients' symptoms. The presence of micro …

Ocular surface itch and pain: key differences and similarities between the two sensations

S Raolji, P Kumar, A Galor - Current opinion in allergy and clinical …, 2023 - journals.lww.com
Ocular surface itch and pain: key differences and similariti... : Current Opinion in Allergy and
Clinical Immunology Ocular surface itch and pain: key differences and similarities between the …

Topical pain control for corneal abrasions: A systematic review and meta‐analysis

CW Yu, A Kirubarajan, M Yau… - Academic …, 2021 - Wiley Online Library
Objectives Corneal abrasions are common ophthalmic presentations to emergency
departments. Among emergency physicians and ophthalmologists, there are highly variable …