The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

Ureases (EC 3.5. 1.5) are Ni2+‐dependent metalloenzymes produced by plants, fungi and
bacteria that hydrolyze urea to produce ammonia and CO2. The insertion of nickel atoms …

Urease in Cryptococcus neoformans plays an important role in fungal dissemination to the
brain and causing meningoencephalitis. Although urea is not required for synthesis of …

Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills over
600,000 people annually. Here, we report integrated computational and experimental …

Morphological switch is tightly coupled with the pathogenesis of many dimorphic fungal
pathogens. Cryptococcus neoformans, the major causative agent of cryptococcal meningitis …

Urease, a major virulence factor for Cryptococcus neoformans, promotes lethal meningitis/
encephalitis in mice. The effect of urease within the lung, the primary site of most invasive …

Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

Blocking of nutrient uptake and amino acid biosynthesis are considered potential targets for
next-generation antifungal drugs against pathogenic fungi, including Cryptococcus …

Efficient communication with the environment is critical for all living organisms. Fungi utilize
complex signalling systems to sense their environments and control proliferation …