Compound YM-60828 was previously characterized in our laboratory as a potent, selective
and orally-bioavailable Factor Xa (FXa) inhibitor. The L-shape conformation of this …

Factor Xa (FXa) is a serine protease which plays a pivotal role in the coagulation cascade.
The inhibition of FXa has received great interest as a potential target for the development of …

Factor Xa (FXa) plays a significant role in the blood coagulation cascade and it has become
a promising target for anticoagulation drugs. Three oral direct FXa inhibitors have been …

The coagulation enzyme factor Xa (fXa) plays a crucial role in the blood coagulation
cascade. In this study, three-dimensional fragment based drug design (FBDD) combined …

Abstract The coagulation factor Xa (FXa) plays a central role in the blood coagulation
cascade. Recent studies have shown that FXa is a particularly attractive target for the …

Since Factor Xa (FXa) is well known to play a central role in thrombosis and hemostasis,
inhibition of FXa is an attractive target for antithrombotic strategies. As a part of our …

Factor Xa (fXa) is a serine protease that plays a pivotal role in the coagulation cascade. High-
throughput screening of the Yamanouchi compound library yielded lead compound 1 with …

Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing
effective and safe anticoagulants. Although a large number of FXa inhibitors have been …

Direct inhibition of FXa has emerged as an effective strategy to achieve anticoagulation
maintaining normal hemostasis with minimal bleeding risks. A novel series of …

Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral
analysis. Modification of lead compound 7 by transformation of its N-oxide 6–6 biaryl ring …