Background: Despite the introduction of direct oral anticoagulants, the search for new oral
anticoagulants remains an urgent task. Objective: By using docking and scoring, based on …

Background: Factor Xa (FXa) is known to play a central role in blood coagulation cascade
and considered to be one of the most attractive targets for oral anticoagulants of new …

Factor Xa is an attractive biological target in the discovery and development of either
parenteral or orally active anticoagulant agents. Several strategies have been utilized at …

Further optimization of the β-aminoester class of factor Xa (fXa) inhibitors is described
culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with …

A series of low molecular weight peptide inhibitors of factor Xa, unrelated to any previously
described, was identified by screening a combinatorial peptide library composed of l-amino …

Factor Xa is a serine protease representing a crucial element in the coagulation process and
an attractive target for anticoagulant therapy. At the present time there are several chemical …

The discovery and subsequent clinical use of coumarins, in the 1950s and of heparin in the
1970s allowed, for the first time, rational treatment of thrombotic diseases. However, in spite …

Due to its critical role in the coagulation cascade Factor Xa became an important target for
antithrombotic drug development. The design of the first generation of Factor Xa inhibitors …

The antithrombotic efficacy of low molecular weight heparins suggest that specific inhibition
of blood coagulation factor Xa (fXa) is an appropriate target for drug discovery. Clinical …

DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITIES OF ORALLY ACTIVE COAGULATION
FACTOR Xa INHIBITORS Page 1 DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITIES OF …