Circumvention of apoptotic machinery is one of the distinctive properties of carcinogenesis.
Extensively established key effectors of such apoptotic bypass mechanisms, the …

Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating
programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals …

Simple Summary The development of BCL-2 inhibitors as a pivotal approach in cancer
treatment lies in their ability to effectively trigger apoptosis in tumor cells. Venetoclax, a …

Since the discovery of apoptosis as a form of programmed cell death, targeting the apoptosis
pathway to induce cancer cell death has been a high-priority goal for cancer therapy. After …

The ability of a cancer cell to avoid apoptosis is crucial to tumorigenesis and can also
contribute to chemoresistance. The Bcl-2 family of prosurvival proteins (Bcl-2, Bcl-XL, Bcl-w …

Simple Summary Apoptosis, a programmed form of cell death, represents the main
mechanism by which cells die. Such phenomenon is highly regulated by the BCL-2 family of …

Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells
to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of …

The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is
responsible for a cell's fate. Due to the recognized relevance of this family in cancer …

Antiapoptotic BCL2 proteins play a major role in tumor cell survival. Hence, BCL2 inhibitors
have been developed as direct inducers of apoptosis. ABT-199 (venetoclax) received …

The removal of cells by apoptosis is an essential process regulating tissue homeostasis.
Cancer cells acquire the ability to circumvent apoptosis and survive in an unphysiological …