Calcineurin modulates environmental stress survival and virulence of the human fungal
pathogen Cryptococcus neoformans. Previously, we identified 44 putative calcineurin …

Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal
pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels …

The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause
disease is dependent on their ability to overcome an onslaught of stresses including …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

ABSTRACT A library of more than 4,500 signature-tagged insertion mutants of the human
pathogenic fungus Cryptococcus neoformans was generated, and a subset was screened in …

Abstract Cyclosporin A (CsA) and FK506 are antimicrobial, immunosuppressive natural
products that inhibit signal transduction. In T cells and Saccharomyces cerevisiae, CsA and …

The protein phosphatase calcineurin is a key mediator of virulence and antifungal
susceptibility of multiple fungal pathogens including Candida albicans, Cryptococcus …

The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic
changes to promote its survival in specific ecological niches and inside the host. To explore …

Laccase is an important virulence factor for the human pathogen, Cryptococcus neoformans.
In this review, we examine the structural, biological and genetic features of the enzyme and …

The underlying mechanism of thermotolerance, which is a key virulence factor essential for
pathogenic fungi such as Cryptococcus neoformans, is largely unexplored. In this study, our …