Introduction Nociceptive neurons play a critical role in the detection of stimuli evoking actual
or potential tissue injury. In addition, they are involved in neurogenic inflammation by the …

Introduction The unique innervation and anatomic features of dental pulp contribute to the
remarkable finding that any physical stimulation of pulpal tissue is painful. Furthermore …

Previous studies have suggested that neurotransmitter substances from the sympatho-
adrenomedullary system regulate pulpal blood flow (PBF), in part, by the inhibition of …

Dental pulp is richly innervated with neurons containing calcitonin gene-related peptide
(CGRP) or substance P (SP). Prior studies have demonstrated that inflammation alters these …

The mechanisms underlying trigeminal pain conditions are incompletely understood. In vitro
animal studies have elucidated various targets for pharmacological intervention; however, a …

Alpha adrenergic agonists (eg vasoconstrictors) represent one of the most commonly used
drug classes in dentistry. Although adrenergic agonists have potent vascular effects, recent …

We have studied the response of nerve fibers containing calcitonin gene‐related peptide
immunoreactivity (CGRP‐IR) to inflammation using a rat dental experimental system …

Neuropeptides released from axons of primary afferent nociceptive neurons are the key
elements for the incidence of neurogenic inflammation and their release is associated with …

Purpose. This study quantified the expression of substance P (SP), calcitonin gene-related
peptide (CGRP), β-endorphins (β-End), and methionine-enkephalin (Met-Enk) in human …

Aim To determine if desensitization of the nociceptive innervation in the dental pulp has an
effect on odontoblast function in the rat. Methodology Neonatal systemic application of …