Background: Mounting evidence suggests that inflammation is involved in the
pathophysiology of both Major Depressive Disorder (MDD) and schizophrenia. The …

Introduction: Schizophrenia is a debilitating mental disorder whose pathogenesis is still not
entirely clear. However, mounting evidence suggests that immune function is involved and a …

Schizophrenia is a complex disease whose pathophysiology is not yet fully understood. In
addition to the long prevailing dopaminergic hypothesis, the evidence suggests that …

Background: A growing body of literature suggesting a prominent role of neuroinflammation
in schizophrenia. Positron emission tomography (PET) imaging using ligands that bind to …

The notion that inflammation and immune signals may play a role in the pathophysiology of
psychiatric conditions has been gaining considerable support. In no small part, this support …

Neuroinflammation is an early feature of a number of nervous system disorders.
Inflammation in the brain is primarily mediated via microglial cells, which are active …

Objective: The purpose of this study was to determine whether microglial activity, measured
using translocator-protein positron emission tomography (PET) imaging, is increased in …

Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

Prior studies indicated that neuroinflammation might play a role in the pathophysiology of
major depressive disorder (MDD). The purpose of this study was to examine changes in a …

Background: Epidemiological, genetic and clinical evidence all indicates that inflammation
plays a role in schizophrenia. Microglia are the resident immune cells of the CNS and act as …