Introduction Progranulin (GRN) mutations occur in frontotemporal lobar degeneration
(FTLD) and in Alzheimer's disease (AD), often with TDP‐43 pathology. Methods We …

Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar
degeneration (FTLD) with ubiquitin and TAR DNA-binding protein 43 (TDP43)-positive …

Importance Mutations in the progranulin gene are known to cause diverse clinical
syndromes, all attributed to frontotemporal lobar degeneration. We describe 2 patients with …

Background Mutation in the progranulin gene (GRN) can cause frontotemporal dementia
(FTD). However, it is unclear whether some rare FTD-relatedGRNvariants are pathogenic …

Background: Progranulin (GRN) mutations in frontotemporal dementia (FTD) have been less
frequently reported in China than in Western countries. Objective: This study reports a novel …

Objective: Loss-of-function mutations in the progranulin gene (PGRN) were identified in
frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal …

Null mutations in progranulin gene (GRN) reduce the progranulin production resulting in
haploinsufficiency and are tightly associated with tau‐negative frontotemporal lobar …

A subset of frontotemporal dementia cases are neuropathologically defined by tau-negative,
TAR DNA-binding protein-43, and ubiquitin-positive inclusions in the brain and are …

Abstract Background and Objective: Reduced progranulin levels are a hallmark of
frontotemporal dementia (FTD) caused by loss-of-function (LoF) mutations in the progranulin …

Progranulin (GRN) mutations are associated with different clinical phenotypes, including
Frontotemporal Lobar Degeneration (FTLD), Corticobasal Degeneration and Alzheimer's …