Affinity maturation and terminal differentiation of B cells via the germinal center reaction is a
complex multistep process controlled by transcription factors that induce or suppress large …

While follicular lymphoma (FL) is exquisitely responsive to immuno-chemotherapy, many
patients follow a relapsing remitting clinical course driven in part by a common precursor cell …

The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …

Appreciation of the epigenome in determining lymphoma clonal heterogeneity and in driving
lymphoma phenotypes through altered promoter and enhancer histone modification profiles …

B cell lymphomas comprise a heterogeneous group of genetically, biologically, and clinically
distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the …

The capacity of the adaptive immune system to respond to antigenic challenges relies on
rapid diversification, expansion, and functional specialization of mature B cells. To …

The germinal center (GC) reaction is a key feature of adaptive humoral immunity. GCs
represent the site where mature B cells refine their B-cell receptor (BCR) and are selected …

Most B-cell lymphomas arise in the germinal center (GC), where humoral immune
responses evolve from potentially oncogenic cycles of mutation, proliferation, and clonal …

The adaptive immune system has evolved to allow effective responses against a virtually
unlimited number of invading pathogens. This process requires the transient formation of …

Follicular lymphoma (FL) is currently incurable using conventional chemotherapy or
immunotherapy regimes, compelling new strategies. Advances in high-throughput …