The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3× Tg-AD) mouse model strain
S Tian, T Ye, X Cheng - Experimental Neurology, 2023 - Elsevier
As a classic animal model of Alzheimer's disease (AD), the 3× Tg-AD mouse not only
recapitulates most of anatomical hallmarks observed in AD pathology but also displays …
recapitulates most of anatomical hallmarks observed in AD pathology but also displays …
Age and gender differences for the behavioral phenotypes of 3xTg Alzheimer's disease mice
The triple transgenic Alzheimer's disease (3xTg-AD) strain is a common mouse model used
for studying the pathology and mechanism of Alzheimer's disease (AD). The 3xTg-AD strain …
for studying the pathology and mechanism of Alzheimer's disease (AD). The 3xTg-AD strain …
Temporal and regional progression of Alzheimer's disease‐like pathology in 3xTg‐AD mice
R Belfiore, A Rodin, E Ferreira, R Velazquez… - Aging cell, 2019 - Wiley Online Library
Accumulation of amyloid‐β (Aβ) and fibrillary tangles, as well as neuroinflammation and
memory loss, are hallmarks of Alzheimer's disease (AD). After almost 15 years from their …
memory loss, are hallmarks of Alzheimer's disease (AD). After almost 15 years from their …
Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model
S Kang, J Kim, KA Chang - Scientific Reports, 2021 - nature.com
Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid
plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent …
plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent …
Investigation of anxiety-and depressive-like symptoms in 4-and 8-month-old male triple transgenic mouse models of Alzheimer's disease
D Várkonyi, B Török, E Sipos, CL Fazekas… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia. Approximately 50% of AD patients show anxiety and depressive …
common form of dementia. Approximately 50% of AD patients show anxiety and depressive …
AβPP accumulation and/or intraneuronal amyloid-β accumulation? The 3xTg-AD mouse model revisited
The triple-transgenic Alzheimer's disease (AD) mouse model, 3xTg-AD, played an important
role in supporting the intraneuronal amyloid-β (Aβ) hypothesis in AD. However, recent …
role in supporting the intraneuronal amyloid-β (Aβ) hypothesis in AD. However, recent …
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes
Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that
differ from those observed in normal aging. Transgenic models of AD are a promising tool in …
differ from those observed in normal aging. Transgenic models of AD are a promising tool in …
Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease
CR Overk, CM Kelley, EJ Mufson - Neurobiology of disease, 2009 - Elsevier
The triple transgenic mouse (3xTgAD), harboring human APPSwe, PS1M146V and
TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as …
TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as …
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction
The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ)
plaques and neurofibrillary tangles. To study the interaction between Aβ and tau and their …
plaques and neurofibrillary tangles. To study the interaction between Aβ and tau and their …
Spontaneous and induced nontransgenic animal models of AD: modeling AD using combinatorial approach
Alzheimer's disease (AD), the most common neurodegenerative and dementing disorder, is
characterized by extracellular amyloid deposition, intracellular neurofibrillary tangle …
characterized by extracellular amyloid deposition, intracellular neurofibrillary tangle …