TNF-α is a pro-inflammatory cytokine that is involved in type 1 diabetes (T1D) pathogenesis.
The TNFa gene is subject of epigenetic regulation in which folate and homocysteine are …

Resumen ARROYO-JOUSSE, Viviana; GARCIA-DIAZ, Diego F y PEREZ-BRAVO, Francisco.
Global DNA methylation and homocysteine levels are lower in type 1 diabetes patients. Rev …

Background The worldwide rise in the incidence of Type 1 Diabetes (T1D), and the
concordance rate between monozygotic twins (50%), indicate a strong effect of the …

Aim The aim of this study was to investigate the relationship between inter-individual global
DNA methylation and diabetes predisposing factors. Methods The 5-methyl cytosine content …

Inter-individual DNA methylation variations were frequently hypothesized to alter individual
susceptibility to Type 2 Diabetes Mellitus (T2DM). Sequence-influenced methylations were …

Introduction The prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is
increasing and several studies suggested an involvement of DNA methylation in the …

Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …

Background Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North
African Arab populations, but the molecular basis for this susceptibility is unknown. Altered …

Methylation has been implied in a number of biological processes and has been shown to
vary under environmental influences as well as in age. Most results on the correlation of …

Aims/hypothesis Epigenetic mechanisms may play an important role in the aetiology of type
2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA …