Interferon-α/β receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006
A Kato, T Homma, J Batchelor, N Hashimoto, S Imai… - BMC immunology, 2003 - Springer
Abstract Background Oligodeoxynucleotides containing unmethylated CpG motifs (CpG
ODN) are known to exert a strong adjuvant effect on Th1 immune responses. Although …
ODN) are known to exert a strong adjuvant effect on Th1 immune responses. Although …
CpG oligodeoxynucleotide developed to activate primate immune responses promotes antitumoral effects in combination with a neoantigen-based mRNA cancer …
Q Li, J Ren, W Liu, G Jiang, R Hu - Drug Design, Development and …, 2021 - Taylor & Francis
Purpose The purpose of our research was to identify and evaluate synthetic
phosphorothioate-modified CPG oligodeoxynucleotides (CPG-ODNs) activating innate and …
phosphorothioate-modified CPG oligodeoxynucleotides (CPG-ODNs) activating innate and …
Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials
CpG oligodeoxynucleotides (ODNs) are promising immunomodulatory agents for treating
human diseases and vaccine development. Phosphodiester CpG ODNs were demonstrated …
human diseases and vaccine development. Phosphodiester CpG ODNs were demonstrated …
CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
RS Chu, OS Targoni, AM Krieg, PV Lehmann… - The Journal of …, 1997 - rupress.org
Synthetic oligodeoxynucleotides (ODN) that contain unmethylated CpG motifs (CpG ODN)
induce macrophages to secrete IL-12, which induces interferon (IFN)-γ secretion by natural …
induce macrophages to secrete IL-12, which induces interferon (IFN)-γ secretion by natural …
Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides
S Pichyangkul, K Yongvanitchit, U Kum-arb… - Journal of …, 2001 - Elsevier
Specially designed oligodeoxynucleotide (ODN) sequences known as 'CpG'ODNs elicit
innate and acquired immune responses. In general, screening of new CpG ODNs has been …
innate and acquired immune responses. In general, screening of new CpG ODNs has been …
A Toll-like receptor recognizes bacterial DNA
H Hemmi, O Takeuchi, T Kawai, T Kaisho, S Sato… - Nature, 2000 - nature.com
DNA from bacteria has stimulatory effects on mammalian immune cells,,, which depend on
the presence of unmethylated CpG dinucleotides in the bacterial DNA. In contrast …
the presence of unmethylated CpG dinucleotides in the bacterial DNA. In contrast …
Development of CpG oligodeoxynucleotide TLR9 agonists in anti-cancer therapy
ABSTRACT Introduction Toll-like receptor-9 (TLR9) can recognize the foreign unmethylated
CpG DNA, and thus intrigue a strong Th1 response which plays a crucial role in the innate …
CpG DNA, and thus intrigue a strong Th1 response which plays a crucial role in the innate …
Antitumor activity mediated by CpG: the route of administration is critical
Abstract Unmethylated CpG oligodeoxynucleotides (CpG) are synthetic toll-like receptor 9
agonists that activate innate immune cells and which have been tested as an immune …
agonists that activate innate immune cells and which have been tested as an immune …
Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor
HM Liu, SE Newbrough, SK Bhatia… - Blood, The Journal …, 1998 - ashpublications.org
Immunostimulatory oligodeoxynucleotides containing the CpG motif (CpG ODN) can activate
various immune cell subsets and induce production of a number of cytokines. Prior studies …
various immune cell subsets and induce production of a number of cytokines. Prior studies …
Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity
CpG DNA induces potent Th1 immune responses through Toll-like receptor 9. In the present
study, we used oligonucleotides consisting of a novel 3′-3′-linked structure and synthetic …
study, we used oligonucleotides consisting of a novel 3′-3′-linked structure and synthetic …