The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients
I Lunde, S Bremer, K Midtvedt, B Mohebi… - European journal of …, 2014 - Springer
Abstract Purpose Tacrolimus (Tac) and cyclosporine (CsA) are mainly metabolized by
CYP3A4 and CYP3A5. Several studies have demonstrated an association between the …
CYP3A4 and CYP3A5. Several studies have demonstrated an association between the …
Impact of POR* 28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients
L Elens, DA Hesselink, R Bouamar… - Therapeutic drug …, 2014 - journals.lww.com
Background: The P450 oxidoreductase (POR)* 28 variant allele has been associated with
altered cytochrome P450 3A enzyme activities. Both CYP3A5 and CYP3A4 are involved in …
altered cytochrome P450 3A enzyme activities. Both CYP3A5 and CYP3A4 are involved in …
Influence of Combined CYP3A4 and CYP3A5 Single-Nucleotide Polymorphisms on Tacrolimus Exposure in Kidney Transplant Recipients: A Study According to the …
K Aouam, A Kolsi, E Kerkeni, N Ben Fredj… - …, 2015 - Taylor & Francis
Aim: The present study investigated in Tunisian renal transplant patients, genetic
polymorphisms of CYP3A4-392A> G and CYP3A5 6986A> G and their influence on …
polymorphisms of CYP3A4-392A> G and CYP3A5 6986A> G and their influence on …
Impact of the CYP3A4*1G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients
M Miura, S Satoh, H Kagaya, M Saito… - …, 2011 - Taylor & Francis
Aim: Tacrolimus is a substrate of CYP3A4 and CYP3A5. The present study investigated the
impact of the CYP3A4* 1/* 1G polymorphism compared with CYP3A5 genotypes on the …
impact of the CYP3A4* 1/* 1G polymorphism compared with CYP3A5 genotypes on the …
The combination of CYP3A4* 22 and CYP3A5* 3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation
N Lloberas, L Elens, I Llaudó, A Padullés… - Pharmacogenetics …, 2017 - journals.lww.com
Results EM had an 88% lower dose-adjusted C 0 compared with IM. PM had a 26% higher
dose-adjusted C 0 compared with IM. The percentage of patients with supratherapeutic Tac …
dose-adjusted C 0 compared with IM. The percentage of patients with supratherapeutic Tac …
Impact of CYP3A4* 22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: toward updated genotype-based dosage guidelines
L Elens, A Capron, RHN van Schaik… - Therapeutic drug …, 2013 - journals.lww.com
Background: Tacrolimus (Tac) metabolism is mainly mediated by the cytochrome P450 3A
(CYP3A) subfamily. Recently, it has been reported that kidney transplant recipients carrying …
(CYP3A) subfamily. Recently, it has been reported that kidney transplant recipients carrying …
Combined effects of CYP3A5* 1, POR* 28, and CYP3A4* 22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal …
DRJ Kuypers, H de Loor, M Naesens… - Pharmacogenetics …, 2014 - journals.lww.com
Aim In a cohort of 298 de-novo renal recipients treated with a standard tacrolimus loading
dose of 0.2 mg/kg, the combined effects of the CYP3A5* 1, POR* 28, and CYP3A4* 22 …
dose of 0.2 mg/kg, the combined effects of the CYP3A5* 1, POR* 28, and CYP3A4* 22 …
Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation
G Gervasini, M Garcia, RM Macias… - Transplant …, 2012 - Wiley Online Library
We retrospectively examined the association of polymorphisms in the CYP3A, CYP2J2,
CYP2C8, and ABCB1 genes with pharmacokinetic (PKs) and pharmacodynamic (PDs) …
CYP2C8, and ABCB1 genes with pharmacokinetic (PKs) and pharmacodynamic (PDs) …
Population Pharmacokinetics of Tacrolimus in Adult Kidney Transplant Patients: Impact of: CYP3A5: Genotype on Starting Dose
Objectives: The aims of this study were to develop a population pharmacokinetic model of
tacrolimus in adult kidney transplant recipients, to use this model to compare cytochrome …
tacrolimus in adult kidney transplant recipients, to use this model to compare cytochrome …
The genetic polymorphisms of POR* 28 and CYP3A5* 3 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients.
JJ Zhang, SB Liu, L Xue, XL Ding, H Zhang… - International Journal of …, 2015 - europepmc.org
Methods Tacrolimus trough whole blood concentrations and clinical details were
retrospectively collected from 83 renal recipients. CYP3A4* 1G, CYP3A5* 3, and ABCB1 …
retrospectively collected from 83 renal recipients. CYP3A4* 1G, CYP3A5* 3, and ABCB1 …