Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

At the request of the Environmental Protection Agency, the National Research Council
(NRC) recently completed a major report entitled Toxicity Testing in the 21st Century: A …

Over the past year, a series on commentaries have appeared in the Toxicological Sciences
Forum Series related to the 2007 National Research Council (NRC) publication, Toxicity …

Over the last decade, several large-scale United States and international programs have
been initiated to incorporate advances in molecular and cellular biology,-omics …

The risk analysis perspective by Daniel Krewski and colleagues lays out the long-term vision
and strategic plan developed by a National Research Council committee (1), sponsored by …

Risk assessment methodologies in toxicology have remained largely unchanged for
decades. The default approach uses high dose animal studies, together with human …

With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …

A new generation of scientific tools has emerged to rapidly measure signals from cells,
tissues, and organisms following exposure to chemicals. High-visibility efforts to apply these …

Background The National Academies' Standing Committee on Use of Emerging Science for
Environmental Health Decisions held a meeting (21–22 September 2009 in Washington …

National Toxicology Program (NTP), funded a project at the National Research Council
(NRC) to develop a long-range vision for toxicity testing and a strategic plan for …