Landmark studies have shown that mutations in kisspeptin and the kisspeptin receptor
(Kiss1r) result in reproductive dysfunction in humans and genetically altered mouse models …

Abstract Kisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a
prerequisite for puberty and reproduction. Animals lacking functional genes for either …

Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed
central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

The hypothalamic hormone GnRH is a central driver of pituitary gonadotropin secretion,
controlling pulsatile gonadotropin secretion, modulating gonadal steroid feedback, and …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

Kisspeptins are a family of hypothalamic neuropeptides that are essential for the regulation
of reproductive physiology. Their importance in reproductive health became apparent in …

The obligatory role of kisspeptin (KISS1) and its receptor (KISS1R) in regulating the
hypothalamic-pituitary–gonadal axis, puberty and fertility was uncovered in 2003. In the few …

Amplification of the neurosecretory activity of the GnRH system is the defining
neuroendocrine event for sexual maturation. The physiological mechanisms that drive …

Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet,
whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of …