PHOTOCHEMISTRY OF 5‐S‐CYSTEINYLDOPA

C Costantini1, M d'Ischia1… - Photochemistry and …, 1994 - Wiley Online Library
The photochemical behavior of 5‐S‐cysteinyldopa (5‐S‐CD), a colorless product of
melanocyte metabolism, was investigated in neutral phosphate buffer with biologically …

PHOTOINITIATED DNA DAMAGE BY MELANOGENIC INTERMEDIATES IN VITRO

W H. Koch, MR Chedekel - Photochemistry and photobiology, 1986 - Wiley Online Library
Cysteinyldopas, metabolic by‐products of activated melanocytes, are photochemically
unstable in the presence of biologically relevant ultraviolet radiation (ie wavelengths> 300 …

5-S-cysteinyldopa and pigment response to UVA light.

E Tegner, H Rorsman, E Rosengren - Acta Dermato-venereologica, 1983 - europepmc.org
5-S-Cysteinyldopa concentrations in serum were studied in healthy individuals exposed to
daily high-intensity UVA radiation. A marked increase in 5-S-cysteinyldopa was found after 3 …

Photobleaching of pheomelanin increases its phototoxic potential: Physicochemical studies of synthetic pheomelanin subjected to aerobic photolysis

A Zadlo, G Szewczyk, M Sarna… - Pigment cell & …, 2019 - Wiley Online Library
Although melanin is a photoprotective pigment, its elevated photochemical reactivity could
lead to various phototoxic processes. Photoreactivity of synthetic pheomelanin, derived from …

Characterisation of 1, 4-benzothiazine intermediates in the oxidative conversion of 5-S-cysteinyldopa to pheomelanins

A Napolitano, C Costantini, O Crescenzi, G Prota - Tetrahedron letters, 1994 - Elsevier
Under biologically relevant conditions, oxidation of 5-S-cysteinyldopa (1) to pheomelanins
proceeds through the formation of the 1, 4-benzothiazine 7 along with the 3-carboxy …

Photochemistry of melanin precursors: Dopa, 5‐S‐Cysteinyldopa and 2, 5‐S, S'‐Dicysteinyldopa

EJ Land, A Thompson, TG Truscott… - Photochemistry and …, 1986 - Wiley Online Library
The photochemistries of the melanin precursors dopa, 5‐S‐cysteinyldopa (5‐SCD) and 2.5‐
S, S'‐dicysteinyldopa (2.5‐SCD) were investigated by 265‐nm laser flash photolysis. The …

Cysteine-dependent 5-S-cysteinyldopa formation and its regulation by glutathione in normal epidermal melanocytes

M Benathan, F Labidi - Archives of dermatological research, 1996 - Springer
Recent evidence suggests that the melanogenesis intermediate 5-S-cysteinyldopa (5-S-CD)
could display antioxidative activity. In the present study, the synthesis of 5-S-CD was …

5-S-cysteinyldopa, a diffusible product of melanocyte activity, is an efficient inhibitor of hydroxylation/oxidation reactions induced by the Fenton system

A Napolitano, S Memoli, AJ Nappi, M d'Ischia… - Biochimica et Biophysica …, 1996 - Elsevier
Interest in 5-S-cysteinyldopa (5-S-CD), a major excretion product of normal and malignant
melanocytes, has traditionally concentrated on its significance as a biosynthetic precursor of …

Urinary excretion of 5-S-cysteinyldopa in relation to skin type, UVB-induced erythema, and melanocyte proliferation in human skin

U Stierner, I Rosdahl, A Augustsson… - Journal of investigative …, 1988 - Elsevier
5-S-Cysteinyldopa (5-S-CD) is found in all pigment-producing cells and is the major
precursor of phaeomelanin. However, the melanocyte specificity of the compound has been …

Plasma 5‐S‐cysteinyldopa as an index of melanogenesis

JE Nimmo, DJ Gawkrodger… - British Journal of …, 1988 - Wiley Online Library
SUMMARY Plasma 5‐S‐cysteinyldopa (5‐S‐CD) concentrations measured in healthy
volunteers in Edinburgh, Scotland (latitude 56 N) showed only minor changes during the …