Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans
RB Conolly, PD Lilly, JS Kimbell - Environmental health perspectives, 2000 - JSTOR
Formaldehyde inhalation causes formation of DNA-protein cross-links (DPX) in the nasal
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …
A distributed-parameter model for formaldehyde uptake and disposition in the rat nasal lining
AV Georgieva, JS Kimbell, PM Schlosser - Inhalation toxicology, 2003 - Taylor & Francis
DNA–protein cross-links (DPX) serve as a dosimeter for inhaled formaldehyde and are
associated with tumor induction in rat nasal passages after chronic exposure to 6 ppm and …
associated with tumor induction in rat nasal passages after chronic exposure to 6 ppm and …
Comparison of inhaled formaldehyde dosimetry predictions with DNA–protein cross-link measurements in the rat nasal passages
EAC Hubal, PM Schlosser, RB Conolly… - Toxicology and applied …, 1997 - Elsevier
Kimbell and coworkers (Toxicol. Appl. Pharmacol. 121,253–263, 1993) developed a
computational fluid dynamics (CFD) model of a F344 rat nasal passage to quantify local wall …
computational fluid dynamics (CFD) model of a F344 rat nasal passage to quantify local wall …
Nasal dosimetry of formaldehyde: Modeling site specificity and the effects of preexposure
HA Heck, M Casanova - Inhalation Toxicology, 1994 - Taylor & Francis
The formation of DNA-protein cross-links (DPX) in the nose of F344 rats exposed to
formaldehyde (HCHO) is site specific and depends on the prior exposure history of the …
formaldehyde (HCHO) is site specific and depends on the prior exposure history of the …
Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined …
RB Conolly, JS Kimbell, D Janszen… - Toxicological …, 2004 - academic.oup.com
Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma
(SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are …
(SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are …
Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: Pharmacolinetics, rat-to-monkey interspecies scaling, and extrapolation …
M Casanova, KT Morgan, WH Steinhagen… - … and applied toxicology, 1991 - Elsevier
DNA-protein cross-links were formed in the respiratory tract of rhesus monkeys exposed to
[14 C] formaldehyde (0.7, 2, or 6 ppm; 6 hr). Concentrations of cross-links (pmol/mg DNA) …
[14 C] formaldehyde (0.7, 2, or 6 ppm; 6 hr). Concentrations of cross-links (pmol/mg DNA) …
Benchmark dose risk assessment for formaldehyde using airflow modeling and a single‐compartment, DNA‐protein cross‐link dosimetry model to estimate human …
PM Schlosser, PD Lilly, RB Conolly… - Risk Analysis: An …, 2003 - Wiley Online Library
Formaldehyde induced squamous‐cell carcinomas in the nasal passages of F344 rats in
two inhalation bioassays at exposure levels of 6 ppm and above. Increases in rates of cell …
two inhalation bioassays at exposure levels of 6 ppm and above. Increases in rates of cell …
Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages
JD Schroeter, J Campbell, JS Kimbell… - Toxicological …, 2014 - academic.oup.com
Formaldehyde is a nasal carcinogen in rodents at high doses and is an endogenous
compound that is present in all living cells. Due to its high solubility and reactivity …
compound that is present in all living cells. Due to its high solubility and reactivity …
Formaldehyde mechanistic data and risk assessment: endogenous protection from DNA adduct formation
CC Conaway, J Whysner, LK Verna… - Pharmacology & …, 1996 - Elsevier
Exposures of rodents to airborne formaldehyde (FA) produce dose-related toxicity,
enhanced cell proliferation and squamous cell carcinomas in the nasal passages. The …
enhanced cell proliferation and squamous cell carcinomas in the nasal passages. The …
[PDF][PDF] Formaldehyde toxicity: DNA-protein cross-linking studies in rats and nonhuman primates
HA Heck, M Casanova, WH Steinhagen… - Nasal Carcinog …, 1989 - edepot.wur.nl
DNA-protein cross-links induced by a single 6-hr exposure to formaldehyde (HCHO) were
measured in the nasal mucosa of F-344 rats and in several regions of the upper respiratory …
measured in the nasal mucosa of F-344 rats and in several regions of the upper respiratory …