Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

Introduction: Transportation of the nutrients and other substances from the blood to the brain
is selectively controlled by the brain capillary endothelial cells that form a restrictive barrier …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Brain delivery is one of the major challenges in drug development because of the high
number of patients suffering from neural diseases and the low efficiency of the treatments …

Among the challenges to the 21st-century health care industry, one that demands special
mention is the transport of drugs/active pharmaceutical agents across the blood–brain …

The blood-brain barrier (BBB), a dynamic and complex barrier formed by endothelial cells,
can impede the entry of unwanted substances–pathogens and therapeutic molecules alike …

The challenge of effectively delivering therapeutic agents to brain has led to an entire field of
active research devoted to overcome the blood brain barrier (BBB) and efficiently deliver …

Peptide and protein therapeutics are generally excluded from transport from blood to brain,
owing to the negligible permeability of these drugs to the brain capillary endothelial wall …

In recent years, there have been several important advancements in the development of
neuropeptide therapeutics. Nevertheless, the targeting of peptide drugs to the CNS remains …

Abstract Blood-Brain Barrier (BBB) is one of the most important physiological barriers strictly
restricting the substance exchange between blood and brain tissues. While the BBB protects …