The role of Slc26a6 (PAT1) on apical Cl−/HCO3− exchange and bicarbonate secretion in
pancreatic duct cells was investigated using Slc26a6 null and wild-type (WT) mice. Apical …

To define the stoichiometry and molecular identity of the Cl−/HCO3− exchanger in the apical
membrane of pancreatic duct cells, changes in luminal pH and volume were measured …

Pancreatic ductal epithelium produces a HCO3−-rich fluid. HCO3− transport across ductal
apical membranes has been proposed to be mediated by both SLC26-mediated Cl−/HCO3 …

The secretin-stimulated human pancreatic duct secretes HCO3−-rich fluid essential for
normal digestion. Optimal stimulation of pancreatic HCO3− secretion likely requires coupled …

SLC26A6 (PAT1, CFEX) is an anion exchanger that is expressed on the apical membrane of
the kidney proximal tubule and the small intestine. Modes of transport mediated by …

Pancreatic duct cells secrete HCO3 (-) ions into a HCO3 (-)-rich luminal fluid (~ 140 mmol/L
in human) against at least a 6-fold concentration gradient. Candidate mechanisms for HCO3 …

Background & Aims: SLC26A6 is a recently identified apical Cl−/HCO3− exchanger with
strong expression in murine duodenum. The present study was designed to examine the …

The basolateral Cl−/HCO 3− exchanger in parietal cells plays an essential role in gastric
acid secretion mediated via the apical gastric H+-K+-ATPase. Here, we report the …

Basal HCO3− secretion across the duodenum has been shown in several species to
principally involve the activity of apical membrane Cl−/HCO3− exchanger (s). To investigate …

CFTR has been recognized to function as both an anion channel and a key regulator of
Slc26 anion transporters in heterologous expression systems. Whether this regulatory …